Dr. Huei-Ru Lin (Rita Lin)
General information
Position
Assistant professor
Work experience
| 2009.02-present | Department of Laboratory Medicine and Biotechnology, Tzu Chi University, Taiwan
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| 2007.10-present | Pesticides Residue Analysis Center, Tzu Chi University, Taiwan
‧Assistant Research Fellow ‧Method development and supervision of technical training of staff ‧Set up the laboratory ‧Set up ISO/IEC17025 system |
| 2007.02-2007.10 | Academia Sinica, Taiwan
‧Postdoctoral Fellow ‧Advised by Prof. Aden Chang ‧Participated in the research project “Splicing factor structure reconstruction” ‧Skills: 100-L scale fermentation, dissection of yeast, protein purification, basic TEM operation, SPIDER software operation (protein complex structure reconstruction) |
| 2006.05-2006.12 | Swiss Federal Institute of Technology in Zurich, Switzerland
Participated in the research program “Serum biomarker search by proteomics” ‧ Advised by Prof. Ruedi Aebersold ‧ Skills: operation of LC-MS (Finnegan LTQ), MALDI-TOF-TOF (ABI 4800), OGE (Agilent, 3100 off-gel electrophoresis), LC-MALDI spotter (LC packing and ABI Tempo), glycopeptides capture method, iTRAQ-labeling assay |
| 1999.07-2006.04 | Center for Drug of Abuse Analysis, Tzu Chi University, Taiwan
Technical staff Advised by Prof. Ahai-Chang Lua ‧ Responsible for routine analysis, quality control, and development of analytical methods ‧ Skills: operation of GC-MS (Agilent) , LC-MS (Finnigan LCQ), EIA (enzyme immunoassay) |
Research
The group develops bioanalytical methods using mass spectrometry. The projects include:
1. Testing of narcotics
The development of bioanalytical tests of amphetamine, ketamine, and opiates, the most commonly abused drugs in Taiwan. The tests will be applied in different samples, such as urine, plasma, saliva, and exhaled breath.
2. Aging
Quantification of advanced glycation end-products (AGEs) in human plasma. We will evaluate the efficiency of derivatization for AGEs using LC-MS/MS.
3. Metabolomics
Quantification of indole-3-acetic acid biosynthesis pathway in bacteria
Identification of drug-resistant strains of bacteria using metabolomic strategy
4. Environment
The development of analytical assays for determining endocrine-disruptor compounds and antibiotics in soil
Publications
- Lin HR*, Choi KI, Lin TC, and Hu A. Simultaneous quantification of amphetamine, opiates, ketamine and relative metabolites in urine for confirmatory analysis by liquid chromatography tandem mass spectrometry. 2013. Journal of chromatography B. 929: 133-141. (SCI, IF= 2.888/rank=23/73=32%; subject categories: Chemistry, analytical)
- Lin HR*, Chen CC, Huang CL, Chen ST, and Lua AC. Simultaneous determination of opiates, methadone, buprenorphine and metabolites in human urine by superficially porous liquid chromatography tandem mass spectrometry. 2013. Journal of chromatography B. 925: 10-15. (SCI, IF= 2.888/rank=23/73=32%; subject categories: Chemistry, analytical)
- Lin HR, Lin HL, Lee SF, Liu S and Lua AC*. A fast screening procedure for ketamine and metabolites in urine samples with tandem mass spectrometry. 2010. J Anal Toxicol 34:149-154. (SCI, IF=2.022, rank: 33/73=45%; subject categories: Chemistry, Analytical 2011).
- Lin HR, Lua AC*. Simultaneous determination of amphetamines and ketamines in urine by gas chromatography/mass spectrometry. 2006. Rapid Communication in Mass Spectrometry 20:1724-1730. (SCI, IF=2.790, rank=33/73=45%; subject categories: Chemistry, Analytical 2011).
Lab photo
From left to right: Chia-Yi Wu, Jia-Yun Taso, Chao-Chuan Liao, Huei-Ru Lin, (rear: Jeng-Han Lin)，Miao-Kuo Kang，Chung-Yu Chang