Dr Shih-yen Lo (2)

Dr. Shih-Yen Lo

General information

Professor and Chairman

Research interests

Research background

  • Expression and characterization of hepatitis B virus polymerase gene in E. coli.
  • Molecular and cellular biology of hepatitis C virus.

 

Special techniques

General molecular biology techniques

 

Research Interests

  • Study on the replication and pathogenesis of hepatitis C virus
  • Study on the replication and pathogenesis of influenza A virus
  • Molecular mechanism(s) of RNA interference

Publications

(* represents the corresponding author)

  1. Shih-Yen Lo, Mark Selby, Myron Tong, Jing-Hsiung Ou* (1994) Comparative studies of the core gene products of two different hepatitis C virus isolates: two alternative forms determined by a single amino acid substitution. Virology. 199(1):124-31.
  2. C T Yeh*, C M Han, Shih-Yen Lo, J H Ou, K D Fan, I S Sheen, C M Chu, and Y F Liaw. (1994) Early detection of anti-HCc antibody in acute hepatitis C virus (HCV) by western blot (immunoblot) using a recombinant HCV core protein fragment. J Clin Microbiol. 32(9): 2235–2241.
  3. SB Hwang, Shih-Yen Lo, Ou JH, Lai MM*. (1995) Detection of Cellular Proteins and Viral Core Protein Interacting with the 5′ Untranslated Region of Hepatitis C Virus RNA. Journal of Biomedical Science 2(3):227-236.
  4. Shih-Yen Lo, FRANK MASIARZ, SOON B. HWANG, MICHAEL M.C. LAI, JING-HSIUNG OU*. (1995) Differential subcellular localization of hepatitis C virus core gene products. Virology. 10;213(2):455-61.
  5. Shih-Yen Lo, Mark Selby, Jing-Hsiung Ou* (1996) Interaction between hepatitis C virus core protein and E1 envelope protein. J Virol. 70(8): 5177–5182.
  6. M Matsumoto, T Y Hsieh, N Zhu, T VanArsdale, S B Hwang, K S Jeng, A E Gorbalenya, Shih-Yen Lo, J H Ou, C F Ware, and M M Lai*. (1997) Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor. J Virol. 71(2): 1301–1309.
  7. Shih-Yen Lo, Jing-Hsiung Ou* (1999) Expression and Dimerization of Hepatitis C Virus Core Protein in E. coli. Methods in Molecular Medicine 19:325-30.
  8. Shih-Yen Lo*, Ke-Feng Peng, Hsin-Chieh Ma, Jui-Hung Yu, Yi-Hwei Li, Hsien-Hong Lin, Ahai-C. Lua, Ming-Liang Lee. (1999) Prevalence of TT virus DNA in eastern Taiwan aborigines. Journal of Medical Virology 59(2):198-203.
  9. Lu W1, Shih-Yen Lo1, Chen M, Wu K, Fung YK, Ou JH*. (1999) Activation of p53 tumor suppressor by hepatitis C virus core protein. Virology 10;264(1):134-41. 1co-first author
  10. Yeh CT*, Shih-Yen Lo, Dai DI, Tang JH, Chu CM, Liaw YF. (2000) Amino acid substitutions in codons 9-11 of hepatitis C virus core protein lead to the synthesis of a short core protein product. J Gastroenterol Hepatol. 15(2):182-91.
  11. Shih-Yen Lo*, Lin HH. (2001) Variations within hepatitis C virus E2 protein and response to interferon treatment. Virus Research 75(2):107-12.
  12. Hsin-Chieh Ma, Ke CH, Hsieh TY, Shih-Yen Lo*. (2002) The first hydrophobic domain of the hepatitis C virus E1 protein is important for interaction with the capsid protein. Journal of General Virology 83(Pt 12):3085-92.
  13. Shih-Yen Lo*, Ku CW, Ma HC, Li YH, Yu JH, Lin HH, Lua AC, Lee ML. (2002) Detection of serologic responses to GB virus C/hepatitis G virus infection. Int J Infect Dis. 6(3):223-7.
  14. Wu YF, Wang LY, Lee TD, Lin HH, Hu CT, Cheng ML, Shih-Yen Lo*. (2004) HLA phenotypes and outcomes of hepatitis B virus infection in Taiwan. Journal of Medical Virology 72(1):17-25.
  15. Wang LY, Lin HH, Lee TD, Wu YF, Hu CT, Cheng ML, Shih-Yen Lo*. (2005) Human leukocyte antigen phenotypes and hepatitis C viral load. Journal of Clinical Virology 32(2):144-50.
  16. Lee YN, Chen LK, Ma HC, Yang HH, Li HP, Shih-Yen Lo*. (2005) Thermal aggregation of SARS-CoV membrane protein. Journal of Virologic Methods 129(2):152-61.
  17. Hsin-Chieh Ma, Yi-Yung Ku, Yi-Ching Hsieh, Shih-Yen Lo＊ (2007) Characterization of the cleavage of signal peptide at the C-terminus of hepatitis C virus core protein by signal peptide peptidase. Journal of Biomedical Science 2007 Jan;14(1):31-41.
  18. Hsin-Chieh Ma, Chiu-Ping Fang, Yi-Ching Hsieh, Shih-Chi Chen, Hui-Chun Li, Shih-Yen Lo＊ (2008) Expression and membrane integration of SARS-CoV M protein. Journal of Biomedical Science 15(3):301-10.
  19. Hsin-Chieh Ma, Ta-Wei Lin , Huichun Li, Sanae M. M. Iguchi-Ariga, Hiroyoshi Ariga, Yu-Li Chuang, Jing-Hsiung Ou, Shih-Yen Lo＊ (2008) Hepatitis C virus ARFP/F protein interacts with cellular MM-1 protein and enhances the gene trans-activation activity of c-Myc. Journal of Biomedical Science 15(4):417-25.
  20. Yi-Ching Hsieh, Hui-Chun Li, Shih-Chi Chen, Shih-Yen Lo＊ (2008) Interactions between M protein and other structural proteins of severe, acute respiratory syndrome-associated coronavirus. Journal of Biomedical Science 15(6):707-17.
  21. Shih-Chi Chen, Shih-Yen Lo, Hsin-Chieh Ma, Hui-Chun Li＊ (2009) Expression and membrane integration of SARS-CoV E protein and its interaction with M protein. Virus Genes 38(3):365-71.
  22. Chia-Wei Chang, Hui-Chun Li, Che-Fang Hsu, Chiao-Yen Chang, Shih-Yen Lo＊ (2009) Increased ATP generation in the host cell is required for efficient vaccinia virus production. Journal of Biomedical Science 2009;16(1):80.
  23. Chee-Hing Yang, Hui-Chun Li, Jeng-Geng Jiang, Che-Fang Hsu, Yi-Jen Wang, Meng-Jiun Lai, Yue-Li Juang, Shih-Yen Lo＊ (2010) Enterovirus type 71 2A protease functions as a transcriptional activator in yeast. Journal of Biomedical Science 2010, 17:65.
  24. Shih-Ching Chan1, Shih-Yen Lo1, Je-Wen Liou, Min-Ching Lin, Ciao-Ling Syu, Meng-Jiun Lai , Yi- Cheng Chen, Hui-Chun Li＊(2011) Visualization of the structures of the hepatitis C virus replication complex. Biochem. Biophys. Res. Commin. 404(1): 574-578. 1co-first author
  25. Rong-Hwa Jan, Teng-Yi Lin, Ya-Chun Hsu, Shiuh-Sheng Lee, Shih-Yen Lo, Mingi Chang, Li-Kuang Chen, Yu-Li Lin* (2011) Immuno-modulatory activity of Ganoderma lucidum-derived polysacharide on human monocytoid dendritic cells pulsed with Der p 1 allergen. BMC Immunology 2011, 12:31.
  26. Wei-Yen Wei, Hui-Chun Li, Chiung-Yao Chen, Chee-Hing Yang, Shen-Kao Lee, Chia-Wen Wang, Hsin-Chieh Ma, Yue-Li Juang, Shih-Yen Lo* (2012) SARS-CoV nucleocapsid protein interacts with cellular pyruvate kinase protein and inhibits its activity. Archives of Virology 157(4):635-45.
  27. Wen-Ta Hu, Hui-Chun Li, Shen-Kao Lee, Hsin-Chieh Ma, Chee-Hing Yang, Hung-Ling Chen, Shih-Yen Lo* (2013) Both core and F proteins of hepatitis C virus could enhance cell proliferation in transgenic mice. Biochem Biophys Res Commun. 435: 147-152.
  28. Betty R. Liu, Jeffrey G. Winiarz , Jong-Sik Moon, Shih-Yen Lo, Yue-Wern Huang, Robert S. Aronstam, Han-Jung Lee* (2013) Synthesis, characterization and applications of carboxylated and polyethylene-glycolated bifunctionalized InP/ZnS quantum dots in cellular internalization mediated by cell-penetrating peptides. Colloids Surf B Biointerfaces. 2013 Jun 2;111C:162-170. doi: 10.1016/j.colsurfb.2013.05.038.
  29. Betty R. Liu, Shih-Yen Lo, Chia-Chin Liu, Chia-Lin Chyan, Yue-Wern Huang, Robert S. Aronstam, Han-Jung Lee* (2013) Endocytic Trafficking of Nanoparticles Delivered by Cell-penetrating Peptides Comprised of Nona-arginine and a Penetration Accelerating Sequence. PLoS One 8, e67100.
  30. Betty R Liu, Ming-Huan Chan, Hwei-Hsien Chen, Shih-Yen Lo, Yue-Wern Huang and Han-Jung Lee* (2013) Effects of Surface Charge and Particle Size of Cell-Penetrating Peptide/Nanoparticle Complexes on Cellular Internalization. Chapter 4 in book of “Cell Membrane: Molecular Structure, Physicochemical Properties and Interactions with the Environment, Editors: Lorette Mandraccia and Gina Slavin”(Nova Science Publishers).
  31. Fang CP, Li ZC, Yang CH, Cheng JC, Yeh YJ, Sun TH, Li HC, Juang YL, Shih-Yen Lo* Hepatitis C virus non-structural protein 3 interacts with cytosolic 5′(3′)-deoxyribonucleotidase and partially inhibits its activity. (2013) PLoS One. Jul 9;8(7):e68736.